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August 14, 2026Scientific ReportsOpen Access

Development of samarium-153 oxide loaded polystyrene radiotracer particles for gamma scintigraphy of whole gastrointestinal transit study

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To develop and evaluate a neutron-activatable, non-absorbable samarium-153 oxide loaded polystyrene radiotracer for whole gastrointestinal transit gamma scintigraphy.
Loaded polystyrene particles (600–800 μm) with samarium-152 oxide and converted them to samarium-153 via neutron activation in a nuclear research reactor.
Characterized particle morphology, size, thermal profile, and radionuclide purity using SEM/EDX, laser diffraction, DSC/TGA, and HPGe gamma spectrometry.
Assessed in vitro radionuclide retention in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) over 120 hours.
Particles achieved a mean specific activity of 57.2 ± 2.0 MBq/g at 48 hours post-irradiation (~5.7 MBq per 100 mg batch) with no detectable long-lived impurities.
Neutron activation preserved particle morphology and size distribution without structural degradation.
Radionuclide retention exceeded 99% in both simulated gastric and intestinal fluids across 120 hours.

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In vitro evaluation reveals high stability and purity of samarium-153 polystyrene particles, indicating a viable low-cost radiotracer for gastrointestinal transit imaging.

Cite This Study

Wong et al. (2026) studied this question.

synapsesocial.com/papers/6a7ec7aab70b84ec8b914301 https://doi.org/10.1038/s41598-026-66901-7

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Implication

In vitro evaluation reveals high stability and purity of samarium-153 polystyrene particles, indicating a viable low-cost radiotracer for gastrointestinal transit imaging.

Development of samarium-153 oxide loaded polystyrene radiotracer particles for gamma scintigraphy of whole gastrointestinal transit study

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Development of samarium-153 oxide loaded polystyrene radiotracer particles for gamma scintigraphy of whole gastrointestinal transit study

Key Points

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Implication

Cite This Study

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