What question did this study set out to answer?

Characterize the magnitude, functional quality, and cross-strain breadth of antibody responses to circulating seasonal influenza A and B viruses in community-dwelling older adults.

August 14, 2026Scientific ReportsOpen Access

Pre-existing and breadth of immunity to seasonal influenza viruses among community-dwelling older adults in Thailand

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Authors

SSSarocha SuthisawatSiriraj Hospital SMSuthee MangmeeSiriraj Hospital KLKatarina LeugersSiriraj Hospital

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Implication

Serosurveillance study reveals limited cross-strain antibody breadth and specific immunity gaps against A/H3N2 in older adults, highlighting the need for enhanced influenza vaccination strategies.

Key Points

Characterize the magnitude, functional quality, and cross-strain breadth of antibody responses to circulating seasonal influenza A and B viruses in community-dwelling older adults.
Analyzed 442 plasma samples collected between 2022 and 2023 from community-dwelling individuals aged ≥60 years residing in high-density urban areas in central Thailand.
Evaluated antibody responses against four circulating influenza strains (A/H1N1, A/H3N2, B/Victoria, and B/Yamagata) using hemagglutination inhibition (HAI; seroprotection defined as titer ≥40) and microneutralization (MNT) assays.
Seroprotection rates and HAI titers were higher against influenza B than influenza A strains, with the lowest overall antibody responses observed against A/H3N2.
Only 15.6% of older adults exhibited broad antibody responses against all four circulating influenza strains, demonstrating limited cross-strain protection.
Neutralizing antibodies were universally detectable with MNT titers exceeding HAI titers across all strains, though B/Victoria demonstrated the highest HAI-to-MNT ratio, indicating reduced functional antibody quality.

Cite This Study

Suthisawat et al. (2026) studied this question.

synapsesocial.com/papers/6a7ec7bab70b84ec8b9145b0 https://doi.org/10.1038/s41598-026-65982-8

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Implication

Serosurveillance study reveals limited cross-strain antibody breadth and specific immunity gaps against A/H3N2 in older adults, highlighting the need for enhanced influenza vaccination strategies.

Pre-existing and breadth of immunity to seasonal influenza viruses among community-dwelling older adults in Thailand

Discussion

Member takes

Implication

Key Points

Cite This Study

Pre-existing and breadth of immunity to seasonal influenza viruses among community-dwelling older adults in Thailand

Discussion

Member takes

Implication

Key Points

Cite This Study

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