March 13, 2018Anesthesia & Analgesia
Implication of Major Adverse Postoperative Events and Myocardial Injury on Disability and Survival: A Planned Subanalysis of the ENIGMA-II Trial
Why the study?
Do major adverse postoperative events and myocardial injury increase the risk of 1-year mortality and disability in noncardiac surgical patients?
Population
6,992 noncardiac surgical patients, ≥45 years of age, with moderate to high cardiac risk
Comparison
Major adverse cardiac events, isolated troponin… vs Patients without these postoperative adverse…
Design
Cohort, MI was blindly adjudicated
Follow-up
1 year
Authors
Discussion
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Member takes
Implication
May inform postoperative surveillance; extends observational mortality data but leaves open disability prediction and interventions.
Structured PICO
Do major adverse postoperative events and myocardial injury increase the risk of 1-year mortality and disability in noncardiac surgical patients?
P
Population
6,992 noncardiac surgical patients, ≥45 years of age, with moderate to high cardiac risk (from the international ENIGMA-II trial cohort)
I
Intervention
Major adverse cardiac events (MACEs), isolated troponin increases, or major adverse postoperative events (MAPEs) with or without troponin elevation
C
Comparator
Patients without these postoperative adverse events (control patients)
O
Outcome
Mortality within 1 postoperative yearhard clinical
Cite This Study
Beattie et al. (2018) studied this question.