Nitrous Oxide and Serious Long-term Morbidity and Mortality in the Evaluation of Nitrous Oxide in the Gas Mixture for Anaesthesia (ENIGMA)-II Trial
Why the study?
Does 70% nitrous oxide increase the risk of death and major cardiovascular events in noncardiac surgery patients at risk of perioperative cardiovascular events?
Population
7,112 noncardiac surgery patients at risk of perioperative cardiovascular events (5,844 evaluated at 1 year)
Comparison
70% nitrous oxide (N2O) vs 70% nitrogen (N2)
Design
RCT, randomly assigned
Follow-up
1 year
Authors
Discussion
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Member takes
Implication
Supports nitrous oxide use without added cardiovascular risk in noncardiac surgery; confirms safety on 1-year death and major events in this RCT.
Structured PICO
Does 70% nitrous oxide increase the risk of death and major cardiovascular events in noncardiac surgery patients at risk of perioperative cardiovascular events?
P
Population
7,112 noncardiac surgery patients at risk of perioperative cardiovascular events (5,844 evaluated at 1 year)
I
Intervention
70% nitrous oxide (N2O)
C
Comparator
70% nitrogen (N2)
O
Outcome
Composite primary outcome of death and major cardiovascular events at 1 year after surgerycomposite
Nitrous oxide administration during noncardiac surgery in patients with known or suspected cardiovascular disease is safe and does not increase the long-term risk of death or major cardiovascular events at 1 year.
Cite This Study
Leslie et al. (2015) studied this question.