Key result
Adding nitrous oxide to isoflurane does not increase adverse outcomes vs. isoflurane alone.
Why the study?
The safety and pharmacologic effects of nitrous oxide administration during anesthesia, including potential age-related risks, were uncertain.
Does the addition of 60% nitrous oxide to isoflurane anesthesia cause major or minor untoward effects in patients undergoing elective surgery?
Population
270 patients scheduled for elective total hip arthroplasty, carotid endarterectomy, or transsphenoidal hypophysectomy
Comparison
Isoflurane with 60% nitrous oxide vs isoflurane without nitrous oxide
Design
Randomized controlled trial with stratification by surgical group
Follow-up
1.5-4 hours anesthesia duration
Authors
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Supports nitrous oxide addition to isoflurane in elective surgery; confirms safety for routine clinical use.
RCT (n=270)
Stratified by surgical group
Does the addition of 60% nitrous oxide to isoflurane anesthesia cause major or minor untoward effects in patients undergoing elective surgery?
The addition of 60% nitrous oxide to isoflurane anesthesia does not increase major or minor adverse effects in patients undergoing elective surgery, supporting its continued clinical use.
Eger et al. (1990) conducted an RCT in Patients requiring anesthesia for elective surgery (n=270). Nitrous oxide (N2O) vs. Isoflurane without N2O was evaluated on Major or minor untoward effects. The addition of 60% nitrous oxide to isoflurane anesthesia did not increase major or minor untoward outcomes compared to isoflurane alone in patients undergoing elective surgery.
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