Key result
Nitrous oxide anesthesia increases isorhythmic AV dissociation ~49% versus no N2O during transsphenoidal hypophysectomy.
Why the study?
Does anesthesia including nitrous oxide increase the incidence of arrhythmias in response to epinephrine administration in patients having transsphenoidal hypophysectomy?
Population
100 patients having transsphenoidal hypophysectomy
Comparison
Anesthesia including nitrous oxide, with all… vs Anesthesia excluding nitrous oxide, with all…
Design
RCT, randomly assigned
Follow-up
postoperative
Authors
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Nitrous oxide raises isorhythmic AV dissociation risk with epinephrine in transsphenoidal surgery; confirms proarrhythmic interaction in this RCT setting.
RCT (n=100)
randomly assigned
Does anesthesia including nitrous oxide increase the incidence of arrhythmias in response to epinephrine administration in patients having transsphenoidal hypophysectomy?
Absolute Event Rate: 61.2% vs 41.2%
The use of nitrous oxide during anesthesia is associated with a higher incidence of isorhythmic AV dissociation in response to epinephrine injection.
Lampe et al. (1990) conducted an RCT in Transsphenoidal hypophysectomy (n=100). Nitrous oxide (N2O) vs. Anesthesia excluding N2O was evaluated on Isorhythmic atrioventricular (AV) dissociation. Nitrous oxide anesthesia during transsphenoidal hypophysectomy resulted in a significantly higher incidence of isorhythmic AV dissociation compared to anesthesia without N2O (61.2% vs 41.2%).
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