Key result
Anesthetic regimens including nitrous oxide did not significantly increase the incidence of intraoperative hypoxemia (5 patients vs 1 patient) or postoperative pulmonary complications.
Why the study?
Does an anesthetic regimen including nitrous oxide increase intraoperative and postoperative pulmonary complications, including hypoxemia, in patients undergoing nonabdominal surgery?
Population
270 patients having nonabdominal surgery.
Comparison
Anesthetic regimen including nitrous oxide, with… vs Anesthetic regimen without nitrous oxide, with a…
Design
RCT, Randomly allocated (stratified within surgical group)
Follow-up
1 week after surgery
Authors
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Supports nitrous oxide inclusion in nonabdominal surgery anesthesia without added pulmonary risk; confirms safety and extends RCT evidence to this setting.
RCT (n=270)
Stratified within surgical group
Does an anesthetic regimen including nitrous oxide increase intraoperative and postoperative pulmonary complications, including hypoxemia, in patients undergoing nonabdominal surgery?
p-value: p=not significant
The inclusion of nitrous oxide in anesthesia for nonabdominal surgery does not significantly increase the risk of postoperative hypoxemia or pulmonary complications.
Lampe et al. (1990) conducted an RCT in Nonabdominal surgery (n=270). Anesthetic regimen with nitrous oxide (N2O) vs. Anesthetic regimen without N2O (with O2) was evaluated on Intraoperative hypoxemia (O2 saturation < 86%) (p=not significant). Anesthetic regimens including nitrous oxide did not significantly increase the incidence of intraoperative hypoxemia (5 patients vs 1 patient) or postoperative pulmonary complications.
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