Key result
Oxygen-nitrous oxide preoxygenation results in similar arterial desaturation to pure oxygen during induction and intubation.
Why the study?
The effects of preoxygenation with oxygen-nitrous oxide mixtures on arterial oxygen saturation during induction and intubation were unclear.
Does preoxygenation with oxygen and nitrous oxide mixtures prevent clinically significant arterial desaturation compared to 100% oxygen in young ASA I patients undergoing elective surgery?
Comparison
Preoxygenation with 100% oxygen vs 50% oxygen:50% nitrous oxide vs 30% oxygen:70% nitrous oxide
Design
Randomized controlled trial
Follow-up
During induction and intubation
Authors
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Supports nitrous oxide-oxygen preoxygenation for smoother induction in healthy young patients; confirms similar desaturation to 100% oxygen in this RCT.
RCT (n=75)
Does preoxygenation with oxygen and nitrous oxide mixtures prevent clinically significant arterial desaturation compared to 100% oxygen in young ASA I patients undergoing elective surgery?
Preoxygenation with oxygen and nitrous oxide mixtures provides similar oxygenation to 100% oxygen during induction of anaesthesia in healthy young patients, while potentially smoothing induction.
Khoo et al. (1993) conducted an RCT in Elective uncomplicated surgery (n=75). Preoxygenation with oxygen and nitrous oxide mixtures (50:50 or 30:70) vs. Preoxygenation with 100% oxygen was evaluated on Arterial oxygen saturation during induction of anaesthesia and intubation. Preoxygenation with oxygen and nitrous oxide mixtures for 1 minute resulted in similar arterial desaturation during induction and intubation compared to 100% oxygen.
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