Why the study?
Does the addition of nitrous oxide alter the hemodynamic effects of anesthesia induction with propofol in ASA I and II patients?
Does the addition of nitrous oxide alter the hemodynamic effects of anesthesia induction with propofol in ASA I and II patients?
The addition of 70% nitrous oxide to propofol induction does not significantly alter the expected hemodynamic changes, such as decreased systolic arterial pressure and cardiac output.
Supports no major hemodynamic interaction in ASA I-II patients; leaves open effects in higher-risk groups or on other endpoints.
Anesthesia was induced in 20 patients, ASA physical status I and II, with either propofol (2.5 mg.kg-1), vecuronium (100 micrograms.kg-1), and 100% oxygen (Group A), or with equal doses of propofol and vecuronium but with 70% nitrous oxide in oxygen (Group B). All patients were premedicated with lorazepam 2 mg orally. In both groups systolic arterial pressure decreased after 3 minutes (P less than 0.05) due to decreases in cardiac output and stroke volume (P less than 0.05). Systemic vascular resistance in both groups did not change immediately after administration of propofol but increased (P less than 0.05) following intubation. Addition of nitrous oxide did not alter hemodynamic parameters associated with propofol induction.
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Carlier et al. (1989) studied this question.
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