Key result
Intraoperative nitrous oxide administration during noncardiac surgery was associated with decreased odds of 30-day mortality (OR 0.67; 97.5% CI 0.46-0.97; P=0.02).
Why the study?
Does intraoperative nitrous oxide administration reduce 30-day mortality and major in-hospital morbidity in adults undergoing general anesthesia for noncardiac surgery?
Observational (n=49,016)
No
Does intraoperative nitrous oxide administration reduce 30-day mortality and major in-hospital morbidity in adults undergoing general anesthesia for noncardiac surgery?
Effect estimate: OR 0.67 (95% CI 0.46-0.97)
p-value: p=0.02
Intraoperative nitrous oxide administration during noncardiac surgery is associated with decreased 30-day mortality and in-hospital morbidity, suggesting it should not be eliminated from anesthetic practice.
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May support reevaluation of nitrous oxide avoidance; leaves open causal benefit pending randomized trials.
Turan et al. (2012) conducted an observational in Noncardiac surgery (n=49,016). Nitrous oxide (N2O) vs. No nitrous oxide was evaluated on 30-day mortality (OR 0.67, 95% CI 0.46-0.97, p=0.02). Intraoperative nitrous oxide administration during noncardiac surgery was associated with decreased odds of 30-day mortality (OR 0.67; 97.5% CI 0.46-0.97; P=0.02).
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