Nitrous Oxide and Long-Term Morbidity and Mortality in the ENIGMA Trial
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Discussion
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Implication
Nitrous oxide exposure was associated with higher long-term myocardial infarction rates; leaves open whether avoidance improves cardiovascular outcomes.
Key Points
- This study aims to evaluate the long-term morbidity and mortality associated with nitrous oxide exposure during noncardiac surgery.
- Review of trial case report forms and medical records for all 2050 randomized patients.
- Follow-up telephone interviews conducted with surviving patients to assess cardiovascular events.
- Primary endpoint was survival, with a median follow-up time of 3.5 years.
- 19% of patients (380) died post-surgery, with 4.5% experiencing myocardial infarction and 2.2% having a stroke.
- Nitrous oxide did not significantly increase mortality risk (HR = 0.98, 95% CI: 0.80 to 1.20; P = 0.82).
- Adjusted odds ratio for myocardial infarction was found to be 1.59 (95% CI: 1.01 to 2.51; P = 0.04), while for stroke it was 1.01 (95% CI: 0.55 to 1.87; P = 0.97).
Cite This Study
Leslie et al. (2010) studied this question.