Key result
Nitrous oxide fails to induce myocardial ischemia in high-risk CAD patients undergoing CABG.
Why the study?
The incidence of myocardial ischemia with nitrous oxide administration in patients with coronary artery disease and poor left ventricular function was uncertain.
Does nitrous oxide induce myocardial ischemia compared to nitrogen in patients with ischemic heart disease and poor ventricular function undergoing elective CABG?
Population
70 patients requiring elective coronary artery bypass grafting, 24% with LVEF ≤40%
Comparison
Nitrous oxide vs equal concentration of nitrogen in a crossover design
Design
Crossover study using two-dimensional transesophageal echocardiography and ECG monitoring
Follow-up
Perioperative period
Authors
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May permit nitrous oxide in high-risk CABG without ischemia concern; leaves open randomized confirmation.
RCT (n=70)
Does nitrous oxide induce myocardial ischemia compared to nitrogen in patients with ischemic heart disease and poor ventricular function undergoing elective CABG?
Nitrous oxide does not induce clinically detectable myocardial ischemia in patients with coronary artery disease and poor left ventricular function undergoing CABG.
Mitchell et al. (1989) conducted an RCT in Ischemic heart disease (n=70). Nitrous oxide vs. Nitrogen was evaluated on Myocardial ischemia. Nitrous oxide did not induce clinically detectable myocardial ischemia in patients with coronary artery disease and poor ventricular function requiring elective coronary bypass grafting.