Key result
Addition of 50% nitrous oxide to fentanyl or enflurane anesthesia in patients with coronary disease caused hemodynamic depression and global myocardial ischemia.
Why the study?
Does the addition of nitrous oxide to fentanyl or enflurane anesthesia impair hemodynamics and myocardial metabolism in patients with coronary artery disease?
Population
20 patients with coronary arterial disease, beta-blocked, scheduled for coronary artery bypass grafts.
Comparison
50% nitrous oxide added to either fentanyl or… vs Baseline measurements before the addition of…
Design
Other
Follow-up
15 minutes
Authors
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May warrant caution with nitrous oxide in CAD patients; leaves open relevance to modern regimens pending randomized data.
Does the addition of nitrous oxide to fentanyl or enflurane anesthesia impair hemodynamics and myocardial metabolism in patients with coronary artery disease?
Nitrous oxide added to fentanyl or enflurane anesthesia causes significant hemodynamic depression and potential myocardial ischemia in patients with coronary artery disease, indicating it may not be safe in this population.
Moffitt et al. (1984) studied Coronary disease (n=20). Nitrous oxide vs. Baseline (before nitrous oxide addition) was evaluated on Hemodynamics and myocardial metabolism (arterial and central pressures, cardiac output, coronary sinus blood flow, oxygen, hemoglobin, and lactate contents). Addition of 50% nitrous oxide to fentanyl or enflurane anesthesia in patients with coronary disease caused hemodynamic depression and global myocardial ischemia.
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