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December 1, 1987Survey of Anesthesiology

Low-Dose Enflurane as Adjunct to High-Dose Fentanyl in Patients Undergoing Coronary Artery Surgery

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Why the study?

Does low-dose enflurane supplementation to high-dose fentanyl anesthesia improve hemodynamics and myocardial oxygenation in patients undergoing coronary artery bypass grafting?

Population

20 patients undergoing coronary artery bypass grafting operations

Comparison

Enflurane supplementation to high-dose fentanyl… vs High-dose fentanyl anesthesia without enflurane…

Design

Cohort

Follow-up

During surgery

Authors

HHHeikki HeikkiläTampere UniversityJJJ. JalonenUniversity of TurkuMAM. ArolaÅbo Akademi University

Discussion

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Implication

May support enflurane use to blunt responses in fentanyl-anesthetized CABG; leaves open randomized confirmation of myocardial oxygenation safety.

Structured PICO

Does low-dose enflurane supplementation to high-dose fentanyl anesthesia improve hemodynamics and myocardial oxygenation in patients undergoing coronary artery bypass grafting?

P
Population
20 patients undergoing coronary artery bypass grafting operations
I
Intervention
Enflurane (end-tidal concentration 0.7%) supplementation to high-dose fentanyl anesthesia (100 micrograms/kg)
C
Comparator
High-dose fentanyl anesthesia (100 micrograms/kg) without enflurane supplementation
O
Outcome
Central and coronary hemodynamics and myocardial oxygenationsurrogate

Low-dose enflurane supplementation to high-dose fentanyl anesthesia safely blunts hemodynamic responses to surgical stimulation during CABG.

Cite This Study

Heikkilä et al. (1987) studied this question.

synapsesocial.com/papers/6a90229bb71d06dae589d74ahttps://doi.org/10.1097/00132586-198712000-00017
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Haemodynamics and Myocardial Oxygenation during Anaesthesia for Coronary Artery Surgery: Comparison between Enflurane and High‐Dose Fentanyl Anaesthesia1985 · 22 citations
  2. 2Myocardial Metabolism and Hemodynamic Responses with Fentanyl-Enflurane Anesthesia for Coronary Arterial Surgery1986 · 8 citations
  3. 3The Effects of Nitrous Oxide on Myocardial Metabolism and Hemodynamics during Fentanyl or Enflurane Anesthesia in Patients with Coronary Disease1984 · 58 citations
  4. 4Haemodynamic Effects and Uptake of Enflurane in Patients Undergoing Cardiac Surgery: Good versus Poor Myocardial Function1992 · 6 citations
  5. 5Anaesthesia for myocardial revascularisation1992 · 24 citations