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November 1, 1992Anaesthesia

Anaesthesia for myocardial revascularisation

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Why the study?

Does propofol compared to enflurane as an adjunct to opioid anesthesia maintain myocardial performance and metabolism in patients undergoing coronary artery bypass grafting?

Population

20 patients undergoing coronary artery bypass grafting

Comparison

Propofol by infusion added to induction with… vs Enflurane added to induction with fentanyl 20…

Design

RCT, random allocation

Follow-up

during surgery

Authors

SUS.M. UnderwoodRoyal London HospitalSDSimon DaviesInterventional / Structural CardiologyRFR.O. FeneckSt Thomas' Hospital

Discussion

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Implication

Propofol maintains equivalent myocardial performance to enflurane during CABG; supports its use as a safe opioid adjunct in cardiac anesthesia.

Structured PICO

Does propofol compared to enflurane as an adjunct to opioid anesthesia maintain myocardial performance and metabolism in patients undergoing coronary artery bypass grafting?

P
Population
20 patients undergoing coronary artery bypass grafting
I
Intervention
Propofol by infusion (6 mg/kg/h reduced by half after 10 min then adjusted as necessary, mean rate 2.8 mg/kg/h) added to induction with fentanyl 20 mcg/kg and pancuronium 0.15 mg/kg
C
Comparator
Enflurane (0.8% inspired concentration for 10 min reduced to 0.6% and adjusted as required, mean 0.7%) added to induction with fentanyl 20 mcg/kg and pancuronium 0.15 mg/kg
O
Outcome
Myocardial performance and metabolism (haemodynamic variables, coronary blood flow, myocardial oxygen consumption, and lactate extraction ratio)surrogate

Propofol is a suitable alternative to enflurane as an adjunct to opioid anesthesia for maintaining myocardial performance and metabolism during coronary artery bypass grafting.

Cite This Study

Underwood et al. (1992) studied this question.

synapsesocial.com/papers/6a7c38a0073f483584dfbe91https://doi.org/10.1111/j.1365-2044.1992.tb03194.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Myocardial Blood Flow and Oxygen Consumption during High-dose Fentanyl Anesthesia in Patients with Coronary Artery Disease1982 · 109 citations
  2. 2Myocardial Metabolism and Hemodynamic Responses to Halothane or Morphine Anesthesia for Coronary Artery Surgery1982 · 30 citations
  3. 3Sufentanil Does Not Block Sympathetic Responses to Surgical Stimuli in Patients Having Coronary Artery Revascularization Surgery1990 · 22 citations
  4. 4Sufentanil Does Not Block Sympathetic Responses to Surgical Stimuli in Patients Having Coronary Artery Revascularization Surgery1989 · 20 citations
  5. 5Myocardial Blood Flow and Oxygen Consumption during High-Dose Fentanyl Anesthesia in Patients with Coronary Artery Disease1983 · 35 citations