January 1, 1997Anesthesia & Analgesia
Hemodynamic Effects, Myocardial Ischemia, and Timing of Tracheal Extubation with Propofol-Based Anesthesia for Cardiac Surgery
Why the study?
Does a propofol-based anesthetic reduce time to tracheal extubation compared to an enflurane-based anesthetic in patients undergoing CABG surgery?
Population
124 patients (34 with poor ventricular function) undergoing coronary artery bypass graft (CABG) surgery
Comparison
Propofol-based anesthetic with induction of… vs Enflurane-based anesthetic with induction of…
Design
RCT, randomized
Follow-up
perioperative (until ICU discharge)
Authors
Discussion
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Member takes
Implication
Propofol enables earlier extubation after CABG; supports its preference over enflurane without affecting ICU discharge.
Structured PICO
Does a propofol-based anesthetic reduce time to tracheal extubation compared to an enflurane-based anesthetic in patients undergoing CABG surgery?
P
Population
124 patients (34 with poor ventricular function) undergoing coronary artery bypass graft (CABG) surgery
I
Intervention
Propofol-based anesthetic (5 mg/kg/h prior to sternotomy, 3 mg/kg/h thereafter) with induction of fentanyl 15 micro g/kg and midazolam 0.05 mg/kg intravenously
C
Comparator
Enflurane-based anesthetic (0.2%-1.0%) with induction of fentanyl 15 micro g/kg and midazolam 0.05 mg/kg intravenously, plus an additional bolus of fentanyl 5 micro g/kg prior to sternotomy and fentanyl 10 micro g/kg with midazolam 0.1 mg/kg at commencement of cardiopulmonary bypass (CPB)
O
Outcome
Time to tracheal extubation
A propofol-based anesthetic significantly reduces time to extubation after CABG surgery compared to an enflurane-based anesthetic, without increasing adverse hemodynamic effects or ischemic events.
Cite This Study
Myles et al. (1997) studied this question.