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January 1, 1997Anesthesia & Analgesia

Effects and Interactions of Nitrous Oxide, Myocardial Ischemia, and Reperfusion on Left Ventricular Diastolic Function

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Why the study?

Does nitrous oxide affect left ventricular diastolic function and interact with ischemia-induced diastolic dysfunction in a canine model?

Population

11 open-chest dogs undergoing 90 min severe low-flow myocardial ischemia and reperfusion, maintained on…

Comparison

60% nitrous oxide (replacing nitrogen) vs 60% nitrogen in oxygen (baseline)

Design

Preclinical

Authors

SMStephan MärschUniversity of BaselSDSerge DalmasNational Institutes of HealthDPDaniel M. PhilbinBrown University

Discussion

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Implication

Nitrous oxide impairs baseline diastolic function without worsening ischemia-induced effects in canines; leaves open clinical translation and should not change practice.

Structured PICO

Does nitrous oxide affect left ventricular diastolic function and interact with ischemia-induced diastolic dysfunction in a canine model?

P
Population
11 open-chest dogs undergoing 90 min severe low-flow myocardial ischemia and reperfusion, maintained on fentanyl infusion
I
Intervention
60% nitrous oxide (replacing nitrogen)
C
Comparator
60% nitrogen in oxygen (baseline)
O
Outcome
Left ventricular diastolic function (chamber stiffness, myocardial stiffness, unstressed length, peak lengthening rate) and regional contractilitysurrogate

Nitrous oxide negatively affects regional diastolic function and contractility at baseline but does not exacerbate ischemia-induced dysfunction in a canine model.

Cite This Study

Märsch et al. (1997) studied this question.

synapsesocial.com/papers/6a82a3ef8ddd99b9b523a2dahttps://doi.org/10.1097/00000539-199701000-00007
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Effects of Nitrous Oxide on Left Ventricular Systolic and Diastolic Performance Before and After Cardiopulmonary Bypass1995 · 48 citations
  2. 2Recovery of Contractile Function of Stunned Myocardium in Chronically Instrumented Dogs is Enhanced by Halothane or Isoflurane1988 · 243 citations
  3. 3Reversal of Volatile Anesthetic-induced Depression of Myocardial Contractility by Extracellular Calcium Also Enhances Left Ventricular Diastolic Function1993 · 46 citations
  4. 4Alteration of Left Ventricular Diastolic Function by Desflurane, Isoflurane, and Halothane in the Chronically Instrumented Dog with Autonomie Nervous System Blockade1991 · 93 citations
  5. 5Alteration of Canine Left Ventricular Diastolic Function1992 · 76 citations