Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 1997Anesthesia & Analgesia

Effects and Interactions of Nitrous Oxide, Myocardial Ischemia, and Reperfusion on Left Ventricular Diastolic Function

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does nitrous oxide affect left ventricular diastolic function in ischemic and nonischemic myocardium in a canine model?

Population

11 open-chest dogs

Comparison

60% nitrous oxide (replacing nitrogen) vs 60% nitrogen in oxygen (baseline)

Design

Preclinical

Follow-up

90 min ischemia and reperfusion

Authors

SMStephan MärschUniversity of BaselSDSerge DalmasNational Institutes of HealthDPDaniel M. PhilbinBrown University

Discussion

Loading...

Member takes

Implication

Should not yet influence nitrous oxide use in ischemia; hypothesis-generating for diastolic effects in translational models.

Structured PICO

Does nitrous oxide affect left ventricular diastolic function in ischemic and nonischemic myocardium in a canine model?

P
Population
11 open-chest dogs
I
Intervention
60% nitrous oxide (replacing nitrogen)
C
Comparator
60% nitrogen in oxygen (baseline)
O
Outcome
Left ventricular diastolic function (chamber stiffness, myocardial stiffness, unstressed length, peak lengthening rate) and regional contractilitysurrogate

Nitrous oxide exerts a negative inotropic effect and alters regional diastolic function by increasing myocardial stiffness, though it does not exacerbate ischemia-induced dysfunction.

Cite This Study

Märsch et al. (1997) studied this question.

synapsesocial.com/papers/6a82a3ef8ddd99b9b523a2d9https://doi.org/10.1213/00000539-199701000-00007
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Myocardial Ischemia and Reperfusion Are Associated with an Increased Stiffness of Remote Nonischemic Myocardium1996 · 15 citations
  2. 2Reversal of Volatile Anesthetic-induced Depression of Myocardial Contractility by Extracellular Calcium Also Enhances Left Ventricular Diastolic Function1993 · 46 citations
  3. 3Recovery of Contractile Function of Stunned Myocardium in Chronically Instrumented Dogs is Enhanced by Halothane or Isoflurane1988 · 243 citations
  4. 4Alteration of Left Ventricular Diastolic Function by Desflurane, Isoflurane, and Halothane in the Chronically Instrumented Dog with Autonomie Nervous System Blockade1991 · 93 citations
  5. 5Alteration of Canine Left Ventricular Diastolic Function1992 · 76 citations