Key result
Addition of 70% nitrous oxide to isoflurane or sufentanil decreased regional PRSW slope (from 50 to 28 and 73 to 52, respectively), demonstrating direct negative inotropic actions in dogs.
Why the study?
Does nitrous oxide reduce myocardial contractility in chronically instrumented dogs?
Population
12 chronically instrumented dogs with pharmacologic blockade of the autonomic nervous system, anesthetized…
Comparison
30% and 70% nitrous oxide administered randomly… vs Baseline isoflurane or sufentanil anesthesia alone
Design
Preclinical, 30% and 70% nitrous oxide were administered in a random fashion
Follow-up
30 min of equilibration after each anesthetic intervention
Authors
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May warrant caution with nitrous oxide in impaired contractility; leaves open human translation of canine findings.
RCT (n=12)
Random fashion
Does nitrous oxide reduce myocardial contractility in chronically instrumented dogs?
Nitrous oxide possesses direct negative inotropic actions independent of changes in autonomic nervous system tone.
Pagel et al. (1990) conducted an RCT in Myocardial contractile function (n=12). Nitrous oxide vs. Isoflurane or sufentanil alone was evaluated on Regional preload recruitable stroke work (PRSW) versus end-diastolic length slope. Addition of 70% nitrous oxide to isoflurane or sufentanil decreased regional PRSW slope (from 50 to 28 and 73 to 52, respectively), demonstrating direct negative inotropic actions in dogs.
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