Key result
Inhalation of 40% N2O in patients with occlusive coronary artery disease significantly decreased arterial pressure (5%) and myocardial contractility (14%), and increased LVEDP (21%).
Why the study?
Does inhalation of 40% N2O affect myocardial performance in patients with coronary artery disease?
Population
13 patients total: 9 patients with occlusive disease in two or more coronary arteries with elevation of left…
Comparison
Inhalation of 40% N2O (nitrous oxide) vs Baseline parameters and comparison between…
Design
Cohort
Authors
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N2O may warrant caution in CAD anesthesia; observational data leave open need for RCTs before practice change.
Does inhalation of 40% N2O affect myocardial performance in patients with coronary artery disease?
Inhalation of 40% nitrous oxide depresses myocardial contractility and increases left ventricular end-diastolic pressure in patients with severe coronary artery disease, indicating a negative inotropic effect in this population.
Eisele et al. (1976) studied Coronary-artery disease (n=13). N2O (Nitrous oxide) vs. Patients without angiographically demonstrable coronary arterial disease was evaluated on Arterial pressure, myocardial contractility (dP/dt/CPIP), and LVEDP. Inhalation of 40% N2O in patients with occlusive coronary artery disease significantly decreased arterial pressure (5%) and myocardial contractility (14%), and increased LVEDP (21%).
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