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November 13, 2001Circulation

Allopurinol Improves Myocardial Efficiency in Patients With Idiopathic Dilated Cardiomyopathy

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Why the study?

Does intracoronary allopurinol improve myocardial efficiency in patients with idiopathic dilated cardiomyopathy?

Population

9 patients with idiopathic dilated cardiomyopathy on standard heart failure therapy including ACE inhibitors…

Comparison

Intracoronary allopurinol. vs Baseline measurements prior to infusion.

Design

Cohort

Follow-up

Acute (15 minutes per dose)

Authors

TCThomas P. CappolaDKDavid A. KassRBRonald D. Berger

Discussion

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Overview

May improve efficiency in dilated cardiomyopathy; hypothesis-generating and requires randomized trials before practice change.

Structured PICO

Does intracoronary allopurinol improve myocardial efficiency in patients with idiopathic dilated cardiomyopathy?

P
Population
9 patients with idiopathic dilated cardiomyopathy (ejection fraction 29+/-3%) on standard heart failure therapy including ACE inhibitors and beta-blockers.
I
Intervention
Intracoronary allopurinol (sequential infusions of 0.5, 1.0, and 1.5 mg/min, each for 15 minutes).
C
Comparator
Baseline measurements prior to infusion.
O
Outcome
Myocardial efficiency (dP/dt(max)/MVO(2) and SW/MVO(2)), myocardial oxygen consumption (MVO(2)), peak rate of rise of left ventricular pressure (dP/dt(max)), and stroke work (SW).surrogate

Intracoronary allopurinol improves myocardial efficiency in patients with idiopathic dilated cardiomyopathy by reducing oxygen consumption without compromising mechanical performance.

Cite This Study

Cappola et al. (2001) studied this question.

synapsesocial.com/papers/6a7ed45feb59ba1375fdb48bhttps://doi.org/10.1161/hc4501.098928
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Also Consider

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  5. 5Comparison of ventricular pressure relaxation assessments in human heart failure1999 · 81 citations