Population
Skeletal muscle C2C12 myotubes
Comparison
Starvation vs Control (fed) myotubes
Design
Preclinical
Authors
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C2C12 myotube starvation models diverge transcriptionally from in vivo atrophy; leaves open their validity for studying muscle wasting mechanisms.
A cell-culture starvation model of C2C12 myotubes induces rapid atrophy with a transcriptional profile distinct from in vivo whole muscle atrophy models.
Stevenson et al. (2004) studied this question.
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