Actualization of the problem and understanding of «cute overdrive». Preparations for the regulation of heart rate

The key role in the pathogenesis of cardiovascular diseases is played by sympathetic overdrive - chronic hyperactivation of the sympathoadrenal system, which ultimately leads to its depletion. Heart rate, blood pressure, and plasma renin levels are markers of hypersympathicotonia. In large-scale clinical studies, it was proved that an increased resting heart rate is an independent risk factor for cardiovascular diseases and is associated with an increased risk of death, and the most effective treatment strategy is to prescribe beta-blockers that affect all parts of the sympathetic overdrive, exhibiting additional metabolic effects.