February 1, 1992Journal of Cardiovascular Electrophysiology
Prevention of Sudden Cardiac Death After a First Myocardial Infarction by Pharmacologic or Surgical Antiadrenergic Interventions
Why the study?
Does oxprenolol or selective left cardiac sympathetic denervation reduce sudden cardiac death in patients after a first anterior myocardial infarction?
Population
1,013 patients with a first and anterior myocardial infarction, divided into a high-risk group and a…
Comparison
Oxprenolol 160 mg or selective left cardiac… vs Placebo.
Design
RCT, Randomization took place 30 days postmyocardial infarction…
Follow-up
mean 22 months
Authors
Discussion
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Member takes
Overview
Supports antiadrenergic therapy with oxprenolol or denervation to reduce SCD post-anterior MI; confirms efficacy across high- and low-risk strata.
Structured PICO
Does oxprenolol or selective left cardiac sympathetic denervation reduce sudden cardiac death in patients after a first anterior myocardial infarction?
P
Population
1,013 patients with a first and anterior myocardial infarction, divided into a high-risk group (n=144, survived MI complicated by ventricular tachycardia or fibrillation) and a relatively low-risk group (n=869, MI without these complications).
I
Intervention
Oxprenolol 160 mg or selective left cardiac sympathetic denervation (surgical intervention evaluated in the high-risk group).
C
Comparator
Placebo.
O
Outcome
Sudden cardiac death.hard clinical
Both pharmacologic (oxprenolol) and surgical (left cardiac sympathetic denervation) antiadrenergic interventions significantly reduce sudden cardiac death in post-myocardial infarction patients at both high and low risk.
Limitations
- relatively small size of the high-risk group
Cite This Study
Schwartz et al. (1992) studied this question.