February 26, 2014PLoS ONEOpen Access

Cilostazol Add-On Therapy in Patients with Mild Dementia Receiving Donepezil: A Retrospective Study

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Why the study?

Does cilostazol add-on therapy reduce cognitive decline in patients with dementia receiving donepezil?

Structured PICO

Does cilostazol add-on therapy reduce cognitive decline in patients with dementia receiving donepezil?

Population

156 patients with dementia (initial MMSE < 27 points) who had received donepezil for more than one year and had undergone MMSE at least at two time points, divided into mild (n=70, MMSE 22-26) and moderate/severe (n=86, MMSE <22) dementia.

Intervention

Cilostazol added to donepezil therapy (average daily dose 139 mg/day for moderate/severe group, 121 mg/day for mild group) for at least 6 months.

Comparator

Donepezil alone.

Outcome

Change of total Mini-Mental State Examination (MMSE) score per year.surrogate

Cilostazol add-on therapy significantly suppressed cognitive decline in patients with mild dementia receiving donepezil, but not in those with moderate/severe dementia.

Limitations

Patient selection bias due to retrospective design
Intergroup differences in background factors (cardiovascular risk factors and hippocampal atrophy)
Cognitive function evaluated based only on MMSE rather than multidimensional tests
Small sample size

Discussion

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Implication

Cilostazol add-on was associated with slower decline in mild dementia on donepezil; hypothesis-generating and requires randomized confirmation.

Cite This Study

Ihara et al. (2014) studied this question.

synapsesocial.com/papers/6a7ee2c586f05158719a149e https://doi.org/10.1371/journal.pone.0089516

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Implication

Cilostazol add-on was associated with slower decline in mild dementia on donepezil; hypothesis-generating and requires randomized confirmation.

Cilostazol Add-On Therapy in Patients with Mild Dementia Receiving Donepezil: A Retrospective Study

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Cilostazol Add-On Therapy in Patients with Mild Dementia Receiving Donepezil: A Retrospective Study

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Also Consider

Also Consider