Key result
Pulsed field ablation for atrial fibrillation has been associated with acute kidney injury in recent reports, including 4 of 28 patients in a pilot study.
Why the study?
Recent reports identified acute kidney injury secondary to hemolysis following pulsed field ablation for atrial fibrillation, despite an otherwise reassuring safety profile.
Does pulsed field ablation compared to different energy sources affect the risk of acute kidney injury in patients with atrial fibrillation?
Does pulsed field ablation compared to different energy sources affect the risk of acute kidney injury in patients with atrial fibrillation?
Pulsed field ablation for atrial fibrillation may be associated with acute kidney injury secondary to hemolysis, prompting comparison with other energy sources.
Renal monitoring may be prudent with pulsed field ablation; leaves open whether acute kidney injury risk exceeds that of other energies.
Pulsed field ablation (PFA) is an innovative technology recently adopted for treating atrial fibrillation (AF). Preclinical and clinical studies have reported a reassuring safety profile because of its tissue-specific effect, sparing adjacent tissues.1 However, two cases of acute kidney injury (AKI) secondary to hemolysis after PFA have recently been reported after an uncommonly high number of applications.2,3 Similarly, a subsequent pilot study reported the occurrence of AKI in 4/28 patients after PFA for AF.
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Jordan et al. (2024) studied Atrial fibrillation. Pulsed field ablation was evaluated on Acute kidney injury. Pulsed field ablation for atrial fibrillation has been associated with acute kidney injury in recent reports, including 4 of 28 patients in a pilot study.
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