Experimental and computational study reveals chemoselective aldehyde and imine reduction by a macrocyclic triazole-borane complex, highlighting a non-innocent proton-hydride activation mechanism.
Borane complexes have long been recognized as efficient reducing agents. Among them, amine–borane complexes display a broad range of stability and reactivity, making them attractive for both laboratory and industrial applications. In this contribution, we report the reduction properties of a thermally stable macrocyclic triazole–borane complex ( 1 ) toward carbonyl and imine functional groups. The observed selectivity was investigated using theoretical calculation.
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Marino et al. (2026) studied this question.
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