Key result
Acute pancreatitis can occur in pregnant patients with type IV hyperlipoproteinemia even when triglyceride levels are below 500 mg/dL.
Why the study?
Most cases of hypertriglyceridemia-induced gestational pancreatitis occur with secondary triggers or very high triglyceride levels, and previous cases reported levels above 1,000 mg/dL.
Case Report (n=1)
No
This case demonstrates that acute pancreatitis can occur in pregnant patients with type IV hyperlipoproteinemia even when triglyceride levels are below 500 mg/dL.
Alerts clinicians to pancreatitis risk in pregnant type IV hyperlipoproteinemia below conventional TG cutoffs; leaves open validation in larger cohorts.
Most cases of hypertriglyceridemia (HTG)-induced gestational pancreatitis occur when a person with hyperlipidemia is overweight due to pregnancy or has secondary triggers associated with triglycerides (TGs). In Korea, 6 cases of HTG-induced gestational pancreatitis have been reported, but none of the affected patients had TG levels below 1,000 mg/dL. A 36-year-old female at 30 weeks of gestation was admitted due to pain in her upper abdomen. Initial biochemical analysis revealed a TG level of 260 mg/dL, an amylase level of 2,951 U/L and a lipase level of 3,500 U/L. Abdominal ultrasonography showed pancreatic swelling with a hypoechogenic rim. After several days, the patient was discharged and had a normal delivery at 38 weeks of gestation. This case report is the first to describe acute pancreatitis occurring in the presence of type IV hyperlipoproteinemia even though the TG level was less than 500 mg/dL, contrary to findings in previously reported cases.
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Lee et al. (2019) conducted a case report in Acute Pancreatitis in Pregnancy (n=1). Type IV hyperlipoproteinemia was evaluated on Clinical recovery and delivery outcome. Acute pancreatitis can occur in pregnant patients with type IV hyperlipoproteinemia even when triglyceride levels are below 500 mg/dL.
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