Cardiometabolic Risk Is Associated With Atherosclerotic Burden and Prognosis: Results From the Partners Coronary Computed Tomography Angiography Registry
Why the study?
Does increasing cardiometabolic risk and diabetes severity correlate with atherosclerotic burden and prognosis in patients without prior CAD?
Population
1,118 patients without prior coronary artery disease referred for coronary computed tomography angiography…
Comparison
Stratification by cardiometabolic risk factors… vs Comparison across the different cardiometabolic…
Design
Cohort
Follow-up
mean 3.1 years
Authors
Discussion
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Member takes
Overview
Insulin-requiring T2DM signals highest MACE risk without prior CAD; supports cardiometabolic risk gradients but leaves open causality and requires prospective confirmation.
Structured PICO
Does increasing cardiometabolic risk and diabetes severity correlate with atherosclerotic burden and prognosis in patients without prior CAD?
P
Population
1,118 patients without prior coronary artery disease (CAD) referred for coronary computed tomography angiography (CCTA), mean age 57 ± 13 years.
I
Intervention
Stratification by cardiometabolic risk factors (hypertension, low HDL, hypertriglyceridemia, obesity, and dysglycemia) and diabetes status (no T2DM with <3 or ≥3 risk factors, T2DM without insulin, T2DM with insulin).
C
Comparator
Comparison across the different cardiometabolic risk and diabetes strata.
O
Outcome
Major adverse cardiovascular events (MACE) composed of unstable angina, late coronary revascularization, myocardial infarction (MI), and cardiovascular mortality.composite
Patients without diabetes but with multiple metabolic risk factors have a similar CAD burden and prognosis as those with non-insulin-dependent diabetes, while insulin-requiring diabetes confers the highest risk.
Cite This Study
Hulten et al. (2013) studied this question.