Population
Mouse models of heart failure induced by pressure overload (transverse aortic constriction, TAC)
Comparison
Overexpression of catalase targeted to… vs Wild-type mice receiving TAC or sham surgery
Design
Preclinical
Authors
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Mitochondrial ROS scavenging may mitigate HF proteomic remodeling in mice; leaves open clinical translation pending human trials.
Scavenging mitochondrial ROS with targeted catalase attenuates maladaptive proteomic changes in pressure overload-induced heart failure in mice.
Dai et al. (2011) studied this question.
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