Key result
The non-dipper pattern of nocturnal blood pressure in hypertensive patients was associated with more complex and severe coronary artery lesions, indicated by a significantly higher mean SYNTAX score compared to dippers (14.6 vs 10.3, p<0.001).
Why the study?
Hypertension and coronary artery disease have a strong causal relationship, but the severity and complexity of atherosclerosis in non-dipper hypertensive patients remains undefined.
Does a non-dipper hypertension pattern associate with increased severity of coronary atherosclerosis in hypertensive patients with chronic coronary syndrome?
Cross-Sectional (n=124)
No
Does a non-dipper hypertension pattern associate with increased severity of coronary atherosclerosis in hypertensive patients with chronic coronary syndrome?
In hypertensive patients with chronic coronary syndrome, a non-dipper nocturnal blood pressure pattern is associated with more complex and severe coronary artery lesions compared to a dipper pattern.
Answers are grounded in this paper and cite their sources.
Should not yet change CAD evaluation in hypertensives; leaves open whether non-dipping independently predicts lesion complexity.
It is well known that the hypertension and coronary artery disease show a strong cause and effect relationship, but the severity and complexity of atherosclerosis in non-dipper hypertensive patients is undefined yet. We evaluated the association between dipper or non-dipper hypertension and the extent of coronary atherosclerosis by SYNTAX score, in patients with the chronic coronary syndrome referred for percutan coronary angiography. Hypertensive patients that performed a percutan coronary angiography fo r the first time were included, and the SYNTAX score was computed. According to their ambulatory blood pressure measurements, the hypertensive patients were grouped as dippers and non-dippers. One hundred and twenty-four patients were included. 87 hypertensive patients were accepted as dipper group, and 37 patients were in non-dipper hypertension group. The mean SYNTAX score for dipper group was 10.32.6 and 14.63.9 for non-dipper group (p<0.001). The number of diseased vessels is higher at the non -dipper group (1.51.1 versus 2.21.7, p<0.001). The hypertensive patients that have a high SS were more likely to be non -dipper. In hypertensive patients, the non-dipper pattern of nocturnal blood pressure variations is associated with more complex and severe coronary artery lesions in chronic coronary syndrome.
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Sarıkaya et al. (2021) conducted a cross-sectional in Essential hypertension and chronic coronary syndrome (n=124). Non-dipper hypertension pattern vs. Dipper hypertension pattern was evaluated on Mean SYNTAX score (p=<0.001). The non-dipper pattern of nocturnal blood pressure in hypertensive patients was associated with more complex and severe coronary artery lesions, indicated by a significantly higher mean SYNTAX score compared to dippers (14.6 vs 10.3, p<0.001).
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