Key result
Increased arterial stiffness, measured by brachial-ankle pulse wave velocity, was independently associated with reduced baroreceptor sensitivity in patients with hypertension (standardized coefficient -0.149, P=0.043).
Population
280 subjects with hypertension from a single center in Japan. Excluded: patients on beta-blockers or with…
Design
Cohort
Follow-up
1 year (newly treated) or 1.5 years (ongoing treatment)
Authors
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Supports arterial stiffness contributing to baroreflex impairment in hypertension; leaves open causal role and need for interventional studies.
Observational (n=280)
No
Effect estimate: Standardized coefficient -0.149
p-value: p=0.043
Increased stiffness of large- to middle-sized arteries, rather than central hemodynamics or endothelial dysfunction, independently contributes to abnormal baroreflex regulation in hypertensive patients.
Tomiyama et al. (2014) conducted an observational in Hypertension (n=280). Arterial stiffness (brachial-ankle pulse wave velocity) was evaluated on Independent association between brachial-ankle pulse wave velocity (baPWV) and baroreceptor sensitivity (BRS) (Standardized coefficient -0.149, p=0.043). Increased arterial stiffness, measured by brachial-ankle pulse wave velocity, was independently associated with reduced baroreceptor sensitivity in patients with hypertension (standardized coefficient -0.149, P=0.043).
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