Key result
This review highlights the insular cortex as an important moderator of the human brain-heart axis in association with sex hormones and summarizes sex-specific neuroanatomy in Takotsubo syndrome.
Why the study?
Takotsubo syndrome occurs predominantly in postmenopausal women with emotional stress, but the role of the insular cortex and sex hormones in modulating the brain-heart axis requires review.
Design
Review
Authors
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Should not yet change practice in postmenopausal TTS; leaves open sex-hormone modulation of the insular cortex as a research target.
This review highlights the potential role of the insular cortex and sex hormones in the pathophysiology of Takotsubo syndrome via the brain-heart axis.
Nagai et al. (2022) conducted a review in Takotsubo syndrome. Insular cortex and sex hormones was evaluated. This review highlights the insular cortex as an important moderator of the human brain-heart axis in association with sex hormones and summarizes sex-specific neuroanatomy in Takotsubo syndrome.
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