April 15, 2014Hypertension

Interferon Regulatory Factor 1 Is Required for Cardiac Remodeling in Response to Pressure Overload

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Population

Failing human hearts, hypertrophic murine hearts, transgenic mice with cardiac-specific IRF1 overexpression…

Comparison

Genetic overexpression or knockout of IRF1, and… vs Wild-type/control animals

Design

Preclinical

Authors

DJDing‐Sheng JiangUniversity of Science and Technology of China LLLiangpeng LiChinese Academy of Medical Sciences & Peking Union Medical College LHLing HuangSouth China Agricultural University

Discussion

Member takes

Implication

IRF1-iNOS modulation should not yet inform heart failure care; leaves open its therapeutic relevance beyond murine pressure-overload models.

Structured PICO

Population

Failing human hearts, hypertrophic murine hearts, transgenic mice with cardiac-specific IRF1 overexpression, IRF1-deficient (knockout) mice, global IRF1-knockout rat model, and IRF1-transgenic/iNOS-knockout mice subjected to pressure overload (aortic banding).

Intervention

Genetic overexpression or knockout of IRF1, and combined IRF1-transgenic/iNOS-knockout

Comparator

Wild-type/control animals

Outcome

Cardiac remodeling (hypertrophy, ventricular dilation, fibrosis, and dysfunction)surrogate

The IRF1-iNOS axis is a crucial regulator of pressure overload-induced cardiac remodeling, suggesting IRF1 as a potential therapeutic target for heart failure.

Cite This Study

Jiang et al. (2014) studied this question.

synapsesocial.com/papers/6a7efd73a11f4f846b8ed06e https://doi.org/10.1161/hypertensionaha.114.03229

Topics

Heart failure HFrEF treatment

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Implication

IRF1-iNOS modulation should not yet inform heart failure care; leaves open its therapeutic relevance beyond murine pressure-overload models.

Interferon Regulatory Factor 1 Is Required for Cardiac Remodeling in Response to Pressure Overload

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Interferon Regulatory Factor 1 Is Required for Cardiac Remodeling in Response to Pressure Overload

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider