Key result
Contegra (HR 6.72, P<0.001) and Melody (HR 5.49, P<0.001) bovine jugular vein valves were associated with a significantly higher risk of infective endocarditis compared with homografts.
Why the study?
Infective endocarditis after pulmonary valve replacements in congenital heart disease is a significant concern, motivating an analysis of specific long-term risk factors after percutaneous or surgical replacement.
Does the type of pulmonary valve replacement affect the risk of infective endocarditis in patients with congenital heart disease?
Population
1170 congenital heart disease patients with at least 1 pulmonary valve replacement
Comparison
Different valve types including homograft, heterograft, Melody, Contegra, Edwards Sapien, and mechanical valves
Design
Nationwide registry-based cohort study
Follow-up
Median 10 years per patient
Authors
Loading...
May warrant caution selecting bovine valves for pulmonary replacement; leaves open randomized confirmation in congenital heart disease.
Cohort (n=1,170)
Yes
Does the type of pulmonary valve replacement affect the risk of infective endocarditis in patients with congenital heart disease?
Hazard Ratio: 6.72
Absolute Event Rate: 5.4% vs 1.3%
p-value: p=<0.001
Bovine jugular vein valves (Contegra and Melody) have the highest risk of infective endocarditis after pulmonary valve replacement in congenital heart disease, regardless of surgical or percutaneous deployment.
Stammnitz et al. (2022) conducted a cohort in Congenital heart disease with pulmonary valve replacement (n=1,170). Contegra valves (bovine jugular vein valves) vs. Homografts was evaluated on Infective endocarditis (HR 6.72, p=<0.001). Contegra (HR 6.72, P<0.001) and Melody (HR 5.49, P<0.001) bovine jugular vein valves were associated with a significantly higher risk of infective endocarditis compared with homografts.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: