December 24, 2014Heart
Infective endocarditis of a transcatheter pulmonary valve in comparison with surgical implants
Key result
Melody valved stents and Contegra grafts had significantly lower 5-year survival free of infective endocarditis (84.9% and 87.8%, respectively) compared to homografts (98.7%; P<0.001).
Why the study?
Does the type of RVOT conduit (Melody, Contegra, or homograft) affect the incidence of infective endocarditis in patients with congenital heart disease?
Population
677 patients with congenital heart disease who received 738 valved conduits in the right ventricular outflow…
Comparison
Melody valved stent or Contegra graft vs Cryopreserved homograft (n=517 patients)
Design
Cohort
Follow-up
Melody: 2.0 years; Homograft: 6.5 years; Contegra: 8.8 years
Authors
Discussion
Loading...
Member takes
Implication
Melody implantation may heighten IE risk in congenital patients; leaves open optimal prestenting and prevention strategies for prospective validation.
Study Design
Type
Cohort (n=677)
Multicenter
No
Structured PICO
Does the type of RVOT conduit (Melody, Contegra, or homograft) affect the incidence of infective endocarditis in patients with congenital heart disease?
P
Population
677 patients with congenital heart disease who received 738 valved conduits in the right ventricular outflow tract, evaluated retrospectively for infective endocarditis.
E
Exposure
Melody valved stent (n=107 patients) or Contegra graft (n=53 patients)
C
Comparator
Cryopreserved homograft (n=517 patients)
O
Outcome
Incidence of infective endocarditis (IE)hard clinical
Main Result
Absolute Event Rate: 84.9% vs 98.7%
p-value: p=<0.001
Contegra and Melody valved stents are associated with a significantly higher incidence of infective endocarditis compared to cryopreserved homografts in patients with congenital heart disease.
Cite This Study
Dijck et al. (2014) conducted a cohort in Congenital heart disease requiring pulmonary valve replacement (n=677). Melody valved stent and Contegra graft vs. Cryopreserved homograft was evaluated on Survival free of infective endocarditis at 5 years (p=<0.001). Melody valved stents and Contegra grafts had significantly lower 5-year survival free of infective endocarditis (84.9% and 87.8%, respectively) compared to homografts (98.7%; P<0.001).