Key result
A peak echocardiographic gradient of ≥ 47 mmHg at the time of infective endocarditis diagnosis was strongly associated with the need for Melody valve explantation (OR 10.6, p < 0.001).
Why the study?
Guidelines for the management of Melody transcatheter pulmonary valve infective endocarditis are lacking, and factors associated with surgical valve removal versus antimicrobial therapy remain to be identified.
What clinical and echocardiographic factors predict the need for surgical valve explantation versus successful medical therapy in patients with Melody transcatheter pulmonary valve infective endocarditis?
Cohort (n=66)
Yes
What clinical and echocardiographic factors predict the need for surgical valve explantation versus successful medical therapy in patients with Melody transcatheter pulmonary valve infective endocarditis?
Odds Ratio: 10.6
p-value: p=<0.001
No takes yet. Share an insight, caveat, or question.
Elevated gradients may flag higher explantation risk in pediatric IE; hypothesis-generating and should not yet change practice.
Davtyan et al. (2021) conducted a cohort in Melody transcatheter pulmonary valve infective endocarditis (n=66). Peak echo gradient ≥ 47 mmHg at IE diagnosis vs. Peak echo gradient < 47 mmHg was evaluated on Surgical valve explantation (OR 10.6, p=<0.001). A peak echocardiographic gradient of ≥ 47 mmHg at the time of infective endocarditis diagnosis was strongly associated with the need for Melody valve explantation (OR 10.6, p < 0.001).
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