The NF-κB transcription factor Rel A (p65) is required for myotube atrophy induced by multiple catabolic cytokines (TNF-α, IL-1α, IL-1β, TWEAK) but not IL-6, suggesting distinct mechanisms of cytokine-induced muscle wasting.
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p65 inhibition may selectively mitigate cytokine-driven atrophy; hypothesis-generating for cytokine-specific NF-κB pathways in muscle wasting.
Yamaki et al. (2012) studied this question.
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