Key result
Gene expression profiling identified 185 and 240 genes upregulated by hind limb unloading in wild type mice that were not upregulated in Nfkb1-/- and Bcl-3-/- mice, respectively.
Population
Wild type, Nfkb1-/- (p50 deficient), and Bcl-3-/- mice
Comparison
Unloading (disuse muscle atrophy model) vs Wild type mice compared to Nfkb1-/- and Bcl-3-/…
Design
Preclinical
Authors
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Highlights p50/Bcl-3 targets in disuse atrophy; leaves open translation to human muscle preservation or cardiac cachexia.
This study identifies specific genes and direct targets of p50 and Bcl-3 required to produce the atrophied phenotype in skeletal muscle disuse.
Wu et al. (2011) studied Disuse muscle atrophy. Hind limb unloading vs. Weight-bearing was evaluated on Upregulated genes dependent on p50 and Bcl-3 during unloading. Gene expression profiling identified 185 and 240 genes upregulated by hind limb unloading in wild type mice that were not upregulated in Nfkb1-/- and Bcl-3-/- mice, respectively.
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