Among Chinese hypertensive dyslipidemia patients on lipid-lowering therapy, the overall goal attainment rates for combined BP and LDL-C, BP alone, and LDL-C alone were 22.9%, 31.9%, and 60.1%, respectively.
Cross-Sectional (n=17,096)
Yes
In Chinese outpatients with hypertensive dyslipidemia, goal attainment rates for both BP and LDL-C are remarkably low (22.9%), highlighting a significant gap in secondary prevention and chronic disease management.
The present study comprised 17,096 Chinese hypertensive dyslipidemia patients who received lipid-lowering treatment for > 3 months in order to investigate blood pressure (BP) as well as low-density lipoprotein cholesterol (LDL-C) goal attainment rates in Chinese hypertensive dyslipidemia patients on antidyslipidemia drugs. The factors that interfered with BP, or BP and LDL-C goal attainment rates and antihypertensive treatment patterns, were analyzed. In total, 89.9% of the 17,096 hypertensive dyslipidemia patients received antihypertensive medications mainly consisting of a calcium channel blocker (CCB) (48.7%), an angiotensin receptor antagonist (ARB) (25.4%) and an angiotensin-converting enzyme inhibitor (ACEI) (15.1%). In cardiology departments, usage rates of β-blockers (19.2%) were unusually high compared to other departments (4.0–8.3%), whereas thiazide diuretics were prescribed at the lowest rate (0.3% vs 1.2–3.6%). The overall goal attainment rates for combined BP and LDL-C as well as BP or LDL-C targets were 22.9, 31.9 and 60.1%, respectively. The lowest BP, LDL-C and BP combined with LDL-C goal attainment rates were achieved in endocrine departments (19.9, 48.9 and 12.4%, respectively). Combination therapies showed no benefit particularly for BP goal achievement. A multivariate logistic regression analysis showed that age < 65 years, alcohol consumption, diabetes, coronary heart disease (CHD), cerebrovascular disease (CVD), chronic kidney disease (CKD), body mass index (BMI) ≥ 28 kg/m2 and not achieving total cholesterol goals were independent predictors for achieving BP, LDL-C or combined BP and LDL-C goals. In summary, the BP and LDL-C goal achievement rates in Chinese dyslipidemia outpatients with hypertension were low, especially in endocrine departments. Combination therapies were not associated with improvement of the goal achievement rates. Clinical trial registration number NCT01732952
Yan et al. (Tue,) conducted a cross-sectional in Hypertensive dyslipidemia (n=17,096). Antihypertensive and lipid-lowering therapy was evaluated on Combined BP and LDL-C goal attainment rate. Among Chinese hypertensive dyslipidemia patients on lipid-lowering therapy, the overall goal attainment rates for combined BP and LDL-C, BP alone, and LDL-C alone were 22.9%, 31.9%, and 60.1%, respectively.
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