Key result
Lipid-lowering treatment in post-acute coronary syndrome patients in China achieved an LDL-C goal attainment rate of only 41.2% at 6 months, indicating significant underutilization of therapy.
Why the study?
The study was conducted to determine the low-density lipoprotein cholesterol goal attainment rate in patients with post-acute coronary syndrome in China.
What is the real-world LDL-C goal attainment rate in post-acute coronary syndrome patients in China?
Observational (n=1,103)
Yes
What is the real-world LDL-C goal attainment rate in post-acute coronary syndrome patients in China?
Despite lipid-lowering therapy, LDL-C goal attainment remains low in post-ACS patients in China, highlighting a significant gap between real-world practice and guideline recommendations.
Answers are grounded in this paper and cite their sources.
Underscores implementation gaps in Chinese post-ACS lipid management; leaves open effective strategies to improve attainment.
BACKGROUND: Dyslipidemia International Study II (DYSIS II)-China was conducted to determine the low-density lipoprotein cholesterol (LDL-C) goal (<1.8 mmol/L) attainment rate in patients with post-acute coronary syndrome (ACS). HYPOTHESIS: Compliance with treatment guideline recommendations improves the LDL-C goal attainment rate in post-ACS patients. METHODS: This multicenter prospective observational study conducted at 28 tertiary hospitals determined the LDL-C goal attainment rates at admission and 6-month follow-up in patients on lipid-lowering treatment (LLT) for ≥3 months and those not on LLT (LLT-naive or off LLT for ≥3 months) at admission. Predictors of goal attainment at 6 months were identified using multivariate logistic regression. RESULTS: The LDL-C goal attainment rate at admission in 1102/1103 enrolled patients was 17.1%; it was 41.2% among 752 patients with available lipid results at 6 months. The distance to goal was 0.7 mmol/L at 6 months. Statin monotherapy was the most prescribed LLT. Only 7.7% of patients were receiving statin + ezetimibe and 8.4% of patients were receiving an atorvastatin-equivalent dose of ≥40 mg/day at 6 months. Being male (odds ratio [OR] 1.7, 95% confidence interval [CI] 1.1-2.6) and undergoing percutaneous coronary intervention during index hospitalization (OR 1.5, 95% CI 1.1 to 2.1) were the independent predictors for LDL-C goal attainment. CONCLUSIONS: This real-world DYSIS II study in China reports a low LDL-C goal attainment rate in post-ACS patients even after 6 months of LLT. Lack of intensification of statin therapy and underutilization of combinations suggest gaps between real-world treatment practices and guideline recommendations.
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Gong et al. (2021) conducted an observational in post-acute coronary syndrome (n=1,103). Lipid-lowering treatment was evaluated on LDL-C goal (<1.8 mmol/L) attainment rate at 6 months. Lipid-lowering treatment in post-acute coronary syndrome patients in China achieved an LDL-C goal attainment rate of only 41.2% at 6 months, indicating significant underutilization of therapy.
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