Higher visceral adipose tissue index was significantly associated with an increased risk of cardiovascular disease (OR 2.11) among young and middle-aged adults with prediabetes or diabetes.
Cohort (n=4,227)
Does higher visceral adipose tissue increase the risk of cardiovascular disease in young and middle-aged adults with prediabetes or diabetes?
Visceral adipose tissue has a nonlinear positive association with cardiovascular disease risk in young and middle-aged adults with prediabetes or diabetes, which is partially mediated by HDL-C and systemic inflammation.
Odds Ratio: 2.11 (95% CI 1.12–3.98)
valor p: p=0.022
Visceral adipose tissue (VAT) is a harmful fat linked to cardiovasular disease (CVD). This study aims to investigate the relationship between VAT, as measured by dual-energy X-ray absorptiometry, and CVD risk in young and middle-aged adults with prediabetes or diabetes. This study analyzed data from 4,227 participants aged 18 to 59 years, collected through the National Health and Nutrition Examination Survey. To evaluate the association between VAT and CVD risk, multivariable logistic regression and restricted cubic spline (RCS) regression analyses were employed. Additionally, mediation, subgroup, and sensitivity analyses were performed to ensure the robustness of the results. Upon comprehensive adjustment for confounders, analysis of VAT index (VATI) as a continuous variable revealed that the odds ratio (OR) for CVD incidence was 2.11 (95% CI: 1.12–3.98; P = 0.022). Participants in the highest tertile of VATI demonstrated a 155% increased risk of CVD (OR 2.55, 95% CI: 1.37–4.72, P = 0.004) compared to those in the lowest tertile. RCS regression analysis suggested a nonlinear association between VATI and CVD incidence (P overall < 0.001, P non−linear = 0.027). Furthermore, mediation analysis indicated that high-density lipoprotein cholesterol (HDL-C) and the systemic inflammatory response index (SIRI) mediated 13.34% and 5.42% of association between VATI and CVD risk, respectively. VAT was positively associated with CVD risk among individuals with prediabetes or diabetes in a nonlinear manner. HDL-C and SIRI partially mediate the impact of VAT on CVD incidence, highlighting lipid metabolism and inflammation as potential underlying mechanisms. Nonlinear association: Visceral adipose tissue (VAT) exhibits a nonlinear positive relationship with cardiovascular disease (CVD) risk in adults under 60 with prediabetes or diabetes. Mediating mechanisms: HDL-C and systemic inflammatory response index partially mediate the impact of VAT on CVD incidence, highlighting lipid metabolism and inflammation as potential underlying mechanisms. Clinical implications: Underscoring the importance for clinicians managing patients with cardiometabolic disease to closely monitor the area of VAT and implement appropriate interventions.
Wu et al. (Tue,) conducted a cohort in Prediabetes or diabetes (n=4,227). Visceral adipose tissue index (VATI) vs. Lower visceral adipose tissue index was evaluated on Cardiovascular disease (CVD) incidence (OR 2.11, 95% CI 1.12-3.98, p=0.022). Higher visceral adipose tissue index was significantly associated with an increased risk of cardiovascular disease (OR 2.11) among young and middle-aged adults with prediabetes or diabetes.