Key result
Exercise training and intermittent hypoxia both increase cardiac angiogenic protein expression in rats.
Why the study?
The comparative effects of aerobic training and intermittent hypoxia on angiogenic factors in cardiac tissue needed to be explored.
Does continuous aerobic exercise training or intermittent hypoxia increase the expression of angiogenic factors (Tie-1, HIF-1α, VEGF, and P-AKT) in the cardiac tissue of male Wistar rats?
Does continuous aerobic exercise training or intermittent hypoxia increase the expression of angiogenic factors (Tie-1, HIF-1α, VEGF, and P-AKT) in the cardiac tissue of male Wistar rats?
In a male Wistar rat model, 8 weeks of either continuous treadmill exercise or intermittent hypoxia significantly upregulated cardiac angiogenic proteins (HIF-1α, VEGF, Tie-1, and p-AKT) and increased capillary density, with exercise showing a stronger effect on AKT phosphorylation.
INTRODUCTION: Angiogenesis can be influenced by many factors. The main purpose of the present study was to explore the effect of aerobic training and intermittent hypoxia on angiogenic factors in the cardiac tissue of male Wistar rats. METHODS: Thirty male Wistar rats were randomly divided into one of three groups; normal control (NC), hypoxia (H), and training (T). The Hypoxia group was exposed to chronic periodic and isobaric hypoxia (total pressure PiO2≈760 mmHg, 14% oxygen) for 8 weeks. Animals in the training group ran on a motorized treadmill (22-26 meters per min) for 8 weeks, 5 sessions per week. At the end of the procedure, protein expression of Tie-1, HIF-1a, VEGF, and P-AKT were calculated by an immunoblotting technique in the cardiac tissue. RESULTS: The findings indicated that periodic hypoxia and exercise training substantially raised the expression of the HIF-1a, VEGF, and P-AKT proteins as compared to the NC (P = 0.001). Moreover, chronic treadmill training significantly increased the phosphorylation of AKT as compared to the hypoxia group (P = 0.001), indicating that PI3K/Akt signalling pathway is influenced by exercise training rather than hypoxia. DISCUSSION AND CONCLUSION: It seems that both hypoxia and exercise training are potent stimulators for the induction of angiogenesis signalling pathway.
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Farhadi et al. (2024) studied Cardiac angiogenesis in healthy male Wistar rats (n=30). Continuous aerobic exercise training or intermittent isobaric hypoxia vs. Normal control (standard housing without exercise training or hypoxia) was evaluated on Protein expression of angiogenic factors (HIF-1a, VEGF, P-AKT, and Tie-1) in cardiac tissue at 8 weeks (p=0.001). Both 8-week exercise training and intermittent hypoxia significantly increased cardiac HIF-1a, VEGF, P-AKT, and Tie-1 protein expression compared to control (p=0.001) in male Wistar rats.
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