Key result
Long-term endurance exercise in male rats led to higher oxidative status and altered angiogenic gene expression, including higher VEGF-B, MEF-2c, and MMP-2, and lower ANGPT-1 and HDAC4 (P<0.05).
RCT (n=18)
Randomly assigned
p-value: p=<0.05
Long-term endurance exercise in a rat model is associated with dysregulation of myocardial angiogenesis and increased oxidative stress.
Warrants no change in exercise guidance; leaves open whether endurance training affects human cardiac angiogenesis.
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Maliheh Ardakanizade (2018) reported an RCT. Mid- and long-term endurance exercise vs. Control was evaluated on Angiogenesis and oxidative stress (p=<0.05). Long-term endurance exercise in male rats led to higher oxidative status and altered angiogenic gene expression, including higher VEGF-B, MEF-2c, and MMP-2, and lower ANGPT-1 and HDAC4 (P<0.05).
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