December 26, 2016Circulation JournalOpen Access

Value of 3-Dimensional Speckle Tracking Echocardiography in the Prediction of Microvascular Obstruction and Left Ventricular Remodeling in Patients With ST-Elevation Myocardial Infarction

Q: What is the clinical evidence from this study?

Study design: Observational. Population: ST-segment elevation myocardial infarction (STEMI) (n=71). Intervention: 3-dimensional speckle tracking echocardiography (3D-STE) vs. 2-dimensional speckle tracking echocardiography (2D-STE). Primary outcome: Left ventricular remodeling at 6 months (predicted by Global 3D-CS > -23%) (OR 8.83, 95% CI 2.68-35.52, p=0.0002).

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Key result

Global 3-dimensional circumferential strain > -23% significantly predicted left ventricular remodeling at 6 months following primary PCI for STEMI (OR 8.83).

Why the study?

Does 3-dimensional speckle tracking echocardiography predict microvascular obstruction and left ventricular remodeling in patients with STEMI treated by primary PCI?

Population

71 patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary…

Comparison

3-dimensional speckle tracking echocardiography… vs Cardiac magnetic resonance imaging assessment of…

Design

Cohort

Follow-up

6 months

Authors

ASAkinori Sugano YSYoshihiro Seo TITomoko Ishizu

Discussion

Member takes

Overview

3D circumferential strain > -23% was associated with post-STEMI remodeling; hypothesis-generating for 3D speckle tracking in risk stratification.

Study Design

Type

Observational (n=71)

Multicenter

Structured PICO

Does 3-dimensional speckle tracking echocardiography predict microvascular obstruction and left ventricular remodeling in patients with STEMI treated by primary PCI?

Population

71 patients with a first ST-segment elevation myocardial infarction treated with primary PCI within 24 hours, followed for 6 months to assess left ventricular remodeling.

Exposure

3-dimensional speckle tracking echocardiography (STE) performed early after PCI

Comparator

Cardiac magnetic resonance imaging (CMR) assessment of microvascular obstruction (MVO)

Outcome

Microvascular obstruction (MVO) and left ventricular (LV) remodeling at 6 monthssurrogate

Main Result

Odds Ratio: 8.83 (95% CI 2.68–35.52)

p-value: p=0.0002

3D speckle tracking echocardiography parameters, specifically circumferential strain and area change ratio, are valuable predictors of microvascular obstruction and subsequent LV remodeling after STEMI.

Limitations

Transmural extent of infarct was assessed visually rather than quantitatively.
Segments assessed by STE did not completely correspond with those assessed by CMR.
Patients unable to undergo CMR or echocardiography within 1 week of PCI due to unstable conditions were excluded.

Cite This Study

Sugano et al. (2016) conducted an observational in ST-segment elevation myocardial infarction (STEMI) (n=71). 3-dimensional speckle tracking echocardiography (3D-STE) vs. 2-dimensional speckle tracking echocardiography (2D-STE) was evaluated on Left ventricular remodeling at 6 months (predicted by Global 3D-CS > -23%) (OR 8.83, 95% CI 2.68-35.52, p=0.0002). Global 3-dimensional circumferential strain > -23% significantly predicted left ventricular remodeling at 6 months following primary PCI for STEMI (OR 8.83).

synapsesocial.com/papers/6a7f0cd321eb47f0c49b28cc https://doi.org/10.1253/circj.cj-16-0944

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December 26, 2016Circulation JournalOpen Access

Value of 3-Dimensional Speckle Tracking Echocardiography in the Prediction of Microvascular Obstruction and Left Ventricular Remodeling in Patients With ST-Elevation Myocardial Infarction

View Full Paper

Ask AI

Bookmark

Key result

Global 3-dimensional circumferential strain > -23% significantly predicted left ventricular remodeling at 6 months following primary PCI for STEMI (OR 8.83).

Why the study?

Does 3-dimensional speckle tracking echocardiography predict microvascular obstruction and left ventricular remodeling in patients with STEMI treated by primary PCI?

Population

71 patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary…

Comparison

3-dimensional speckle tracking echocardiography… vs Cardiac magnetic resonance imaging assessment of…

Design

Cohort

Follow-up

6 months

Authors

ASAkinori Sugano YSYoshihiro Seo TITomoko Ishizu

Discussion

Member takes

Overview

3D circumferential strain > -23% was associated with post-STEMI remodeling; hypothesis-generating for 3D speckle tracking in risk stratification.

Study Design

Type

Observational (n=71)

Multicenter

Structured PICO

Does 3-dimensional speckle tracking echocardiography predict microvascular obstruction and left ventricular remodeling in patients with STEMI treated by primary PCI?

Population

71 patients with a first ST-segment elevation myocardial infarction treated with primary PCI within 24 hours, followed for 6 months to assess left ventricular remodeling.

Exposure

3-dimensional speckle tracking echocardiography (STE) performed early after PCI

Comparator

Cardiac magnetic resonance imaging (CMR) assessment of microvascular obstruction (MVO)

Outcome

Microvascular obstruction (MVO) and left ventricular (LV) remodeling at 6 monthssurrogate

Main Result

Odds Ratio: 8.83 (95% CI 2.68–35.52)

p-value: p=0.0002

Limitations

Transmural extent of infarct was assessed visually rather than quantitatively.
Segments assessed by STE did not completely correspond with those assessed by CMR.
Patients unable to undergo CMR or echocardiography within 1 week of PCI due to unstable conditions were excluded.

Cite This Study

synapsesocial.com/papers/6a7f0cd321eb47f0c49b28cc https://doi.org/10.1253/circj.cj-16-0944

Also Consider

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