Clinical Predictors of High Posttreatment Platelet Reactivity to Clopidogrel in Koreans
Why the study?
What are the clinical predictors of high posttreatment platelet reactivity to clopidogrel in Korean patients undergoing coronary angiography?
Population
1,431 consecutive Korean patients undergoing coronary angiography
Design
Cohort
Authors
Discussion
Loading...
Member takes
Implication
May aid HPPR risk stratification on clopidogrel in Koreans; leaves open whether tailored therapy improves outcomes.
Structured PICO
What are the clinical predictors of high posttreatment platelet reactivity to clopidogrel in Korean patients undergoing coronary angiography?
P
Population
1,431 consecutive Korean patients undergoing coronary angiography
I
Intervention
Clopidogrel therapy (posttreatment platelet reactivity measured)
O
Outcome
High posttreatment platelet reactivity to clopidogrel (HPPR), defined as >275 P2Y12 Reaction Unit (PRU) using the VerifyNow P2Y12 assaysurrogate
In Korean patients undergoing coronary angiography, female gender, chronic kidney disease, diabetes mellitus, elevated hs-CRP, and older age are independent predictors of high posttreatment platelet reactivity to clopidogrel.
Cite This Study
Park et al. (2010) studied this question.