March 5, 2014PLoS ONEOpen Access

Chlorogenic Acid Inhibits Human Platelet Activation and Thrombus Formation

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Why the study?

Does chlorogenic acid inhibit platelet activation and thrombus formation in human platelets and murine models?

Population

Human platelets from 6 young healthy volunteers and C57BL/6 mice.

Comparison

Chlorogenic acid vs Vehicle and Aspirin

Design

Preclinical

Authors

EFEduardo FuentesUniversity of Talca JCJulio CaballeroUniversity of Talca MAMarcelo AlarcónUniversity of Talca

Discussion

Member takes

Implication

Supports preclinical antiplatelet effects; leaves open translation to human antithrombotic use.

Structured PICO

Does chlorogenic acid inhibit platelet activation and thrombus formation in human platelets and murine models?

Population

Human platelets from 6 young healthy volunteers and C57BL/6 mice (12-16 weeks old, n=18 for thrombosis model, n=18 for bleeding assay).

Intervention

Chlorogenic acid (0.1 to 1 mmol/L in vitro; 200 mg/kg intraperitoneally in vivo)

Comparator

Vehicle (DMSO 0.2%) and Aspirin (ASA 0.3 mmol/L in vitro; 200 mg/kg intraperitoneally in vivo)

Outcome

Platelet secretion and aggregation, platelet firm adhesion/aggregation under flow conditions, and in vivo thrombus formation and bleeding timesurrogate

Chlorogenic acid demonstrates antiplatelet and antithrombotic effects mediated by the A2A receptor/adenylate cyclase/cAMP/PKA signaling pathway, with less impact on bleeding time than aspirin.

Cite This Study

Fuentes et al. (2014) studied this question.

synapsesocial.com/papers/6a7f0e0abc80c6618cd0a7ec https://doi.org/10.1371/journal.pone.0090699

View Full Paper

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March 5, 2014PLoS ONEOpen Access

Chlorogenic Acid Inhibits Human Platelet Activation and Thrombus Formation

View Full Paper

Ask AI

Bookmark

Why the study?

Does chlorogenic acid inhibit platelet activation and thrombus formation in human platelets and murine models?

Population

Human platelets from 6 young healthy volunteers and C57BL/6 mice.

Comparison

Chlorogenic acid vs Vehicle and Aspirin

Design

Preclinical

Authors

EFEduardo FuentesUniversity of Talca JCJulio CaballeroUniversity of Talca MAMarcelo AlarcónUniversity of Talca

Discussion

Member takes

Implication

Supports preclinical antiplatelet effects; leaves open translation to human antithrombotic use.

Structured PICO

Does chlorogenic acid inhibit platelet activation and thrombus formation in human platelets and murine models?

Population

Human platelets from 6 young healthy volunteers and C57BL/6 mice (12-16 weeks old, n=18 for thrombosis model, n=18 for bleeding assay).

Intervention

Chlorogenic acid (0.1 to 1 mmol/L in vitro; 200 mg/kg intraperitoneally in vivo)

Comparator

Vehicle (DMSO 0.2%) and Aspirin (ASA 0.3 mmol/L in vitro; 200 mg/kg intraperitoneally in vivo)

Outcome

Platelet secretion and aggregation, platelet firm adhesion/aggregation under flow conditions, and in vivo thrombus formation and bleeding timesurrogate

Chlorogenic acid demonstrates antiplatelet and antithrombotic effects mediated by the A2A receptor/adenylate cyclase/cAMP/PKA signaling pathway, with less impact on bleeding time than aspirin.

Cite This Study

Fuentes et al. (2014) studied this question.

synapsesocial.com/papers/6a7f0e0abc80c6618cd0a7ec https://doi.org/10.1371/journal.pone.0090699

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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