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August 10, 2020Open Access

Inhibitory Effect of Protocatechuic Acid on Platelet Aggregation Induced by High Shear Stress

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Why the study?

Bleeding and drug resistance are the most common side effects of clinically used antiplatelet drugs, making it important to identify new antiplatelet agents that avoid or reduce these complications.

Does protocatechuic acid inhibit high shear stress-induced platelet aggregation in human blood samples?

Comparison

Protocatechuic acid vs CD42b, aspirin, tirofiban, and other drugs

Design

In vitro microfluidic chip study

Authors

CHCui HeLYLihua YuWDWenran Dan

Discussion

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Overview

Microfluidic model may aid safer antiplatelet screening; leaves open clinical translation and efficacy.

Structured PICO

Does protocatechuic acid inhibit high shear stress-induced platelet aggregation in human blood samples?

P
Population
Blood samples from 20 healthy volunteers and 10 patients with atherosclerosis.
I
Intervention
Protocatechuic acid (1-16 µg/ml, optimal concentration 8 µg/ml) added to whole blood in vitro.
C
Comparator
Control (0.9% sodium chloride solution) and active comparators (aspirin, tirofiban, CD42b).
O
Outcome
Platelet aggregation induced by high shear stress in a microfluidic chip.surrogate

Protocatechuic acid selectively inhibits high shear stress-induced platelet aggregation via the GP1b-vWF pathway without impairing normal coagulation, suggesting potential as a novel antithrombotic agent.

Limitations

  • The effect of the combination of protocatechuic acid and aspirin or other drugs remains to be studied.
  • In vivo mechanisms and effects remain to be further studied.

Cite This Study

He et al. (2020) studied this question.

synapsesocial.com/papers/6a6f847ff44fa9f079dcf8afhttps://doi.org/10.21203/rs.3.rs-51732/v1
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Platelet Aggregation and Activation under Complex Patterns of Shear Stress2002 · 82 citations
  2. 2Analysis of shear stress and hemodynamic factors in a model of coronary artery stenosis and thrombosis1993 · 204 citations
  3. 3A Scaling Law for Wall Shear Rate Through an Arterial Stenosis1994 · 103 citations