Association between Triglyceride-Glucose Index and Prognosis in Critically Ill Patients with Acute Coronary Syndrome: Evidence from the MIMIC Database

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Acute Coronary Syndrome (critically ill) (n=849). Intervention: Triglyceride-glucose (TyG) index vs. Lower TyG index (lowest quartile). Primary outcome: 28-day all-cause mortality (HR 2.13, 95% CI 1.23-3.68, p=<0.01).

Manqing Chen; Yuhui Yang; Weiwei Hu; Lingmin Gong; Yifan Fu; Xingyan Li; Hongman Feng; Fangyao Chen

doi:10.7150/ijms.107976

February 26, 2025International Journal of Medical SciencesOpen Access

Association between Triglyceride-Glucose Index and Prognosis in Critically Ill Patients with Acute Coronary Syndrome: Evidence from the MIMIC Database

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Key result

A higher TyG index was significantly associated with increased 28-day all-cause mortality (HR 2.13) and 365-day mortality (HR 1.65) in critically ill patients with acute coronary syndrome.

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Why the study?

Does a higher TyG index increase all-cause mortality in critically ill patients with acute coronary syndrome?

Study Design

Type

Observational (n=849)

Multicenter

No

Structured PICO

Does a higher TyG index increase all-cause mortality in critically ill patients with acute coronary syndrome?

P

Population

849 critically ill adult patients with acute coronary syndrome admitted to the ICU, followed for up to 5 years to assess short- and long-term mortality.

E

Exposure

Higher Triglyceride-Glucose (TyG) index, calculated as ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)]/2.

C

Comparator

Lower TyG index (analyzed as quartiles or continuous variable).

O

Outcome

28-day and 365-day all-cause mortality.hard clinical

Main Result

Hazard Ratio: 2.13 (95% CI 1.23–3.68)

p-value: p=<0.01

Limitations

Retrospective observational design makes it difficult to establish causal associations.
Uncertainty regarding whether triglyceride and glucose measurements were taken under fasting conditions.
Only baseline TyG index was available, without data on changes during the follow-up period.
Missing data on the GRACE score and specific causes of hospitalization in the MIMIC database.
Moderate sample size from a single center.

Abstract

A higher TyG index is associated with both short-term and long-term all-cause mortality in critically ill patients with ACS, especially in short-term all-cause mortality. TyG index is associated with higher mortality risk in patient subgroups aged ≤ 70 years old. A higher TyG index is associated with longer time of stay in hospital. TyG index may serve as a useful prognostic marker for patient management and strategic decision-making in clinical settings.

Discussion

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Cite This Study

Chen et al. (2025) conducted an observational in Acute Coronary Syndrome (critically ill) (n=849). Triglyceride-glucose (TyG) index vs. Lower TyG index (lowest quartile) was evaluated on 28-day all-cause mortality (HR 2.13, 95% CI 1.23-3.68, p=<0.01). A higher TyG index was significantly associated with increased 28-day all-cause mortality (HR 2.13) and 365-day mortality (HR 1.65) in critically ill patients with acute coronary syndrome.

synapsesocial.com/papers/6a7f1884e7861671be8ed7f1 https://doi.org/10.7150/ijms.107976

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Association between Triglyceride-Glucose Index and Prognosis in Critically Ill Patients with Acute Coronary Syndrome: Evidence from the MIMIC Database

Figures

Study Design

Structured PICO

Main Result

Limitations

Abstract

Discussion

Cite This Study

Association between Triglyceride-Glucose Index and Prognosis in Critically Ill Patients with Acute Coronary Syndrome: Evidence from the MIMIC Database

Figures

Study Design

Structured PICO

Main Result

Limitations

Abstract

Discussion

Cite This Study

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