Key result
Glycemic variability fails to correlate with oxidative stress in non-diabetic ACS patients presenting with hyperglycemia.
Why the study?
The study aimed to establish the relationship between glycemic variation, oxidative stress, and pre-discharge glycemic status assessed by OGTT in patients presenting with acute coronary syndrome and hyperglycemia.
Does glycemic variation measured by CGMS correlate with oxidative stress (8-isoprostanes) and pre-discharge glycemic status by OGTT in non-diabetic patients presenting with acute coronary syndrome and hyperglycemia?
Cohort (n=19)
No
Does glycemic variation measured by CGMS correlate with oxidative stress (8-isoprostanes) and pre-discharge glycemic status by OGTT in non-diabetic patients presenting with acute coronary syndrome and hyperglycemia?
Answers are grounded in this paper and cite their sources.
All non-diabetic ACS patients presenting with admission random blood sugar ≥200 mg/dl had abnormal glucose tolerance on pre-discharge OGTT (57.9% frank diabetes, 42.1% impaired glucose tolerance), supporting routine pre-discharge OGTT screening despite a lack of correlation between glycemic variability and 8-isoprostanes.
Aim:The aim of this study was to establish the relationship between the glycemic variation in patients of Acute Coronary Syndrome (ACS) with hyperglycemia, oxidative stress and pre-discharge assessment of glycemic status by Oral Glucose Tolerance Test (OGTT). Materials and Method: Nineteen non-diabetic patients who presented with acute coronary syndrome with random blood sugar ≥200 mg/dl were recruited and glycemic variation was measured using CGMS followed by measurement of 8-isoprostanes PG-2alpha as a marker of oxidative stress, and pre-discharge OGTT was done to know the glycemic status at the time of discharge. Result: Mean MAGE (A parameter of glycemic variation) was 106.92±22.66 and mean 8-isoprostanes level was 206.05±179.57. There was no relationship between these two values. On doing OGTT, out of 19 non diabetic patients 11 turned out to be frank diabetic and 8 were having impaired glucose tolerance after OGTT, none were euglycemic. Conclusion:The study highlighted the issue of hyperglycaemia in ACS patients and their abnormal glucose tolerance in the short term, most of them turning to be frankly diabetic and being totally asymptomatic till the time of index event, although no correlation was found between glycemic variability and oxidative stress.
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A 2020 study conducted a cohort in Acute Coronary Syndrome with hyperglycemia (n=19). Glycemic variation measured by Continuous Glucose Monitoring System (CGMS) as Mean Amplitude of Glycemic Excursion (MAGE) was evaluated on Correlation between glycemic variation (MAGE) and oxidative stress (serum 8-isoprostanes PG-2alpha) and pre-discharge glycemic status by Oral Glucose Tolerance Test (OGTT). Glycemic variation (mean MAGE 106.92±22.66) did not correlate with 8-isoprostanes (206.05±179.57) in non-diabetic hyperglycemic ACS patients, though 57.9% had frank diabetes on pre-discharge OGTT.
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